'Deeply Grieved' in the Bible

They were silent. Then looking around upon them with anger, and deeply grieved by the hardening of their hearts, he said to the man, "Stretch out your hand!" He stretched it out, and the hand was at once completely restored.

And [although he] was deeply grieved, the king, because of his oaths and {dinner guests}, did not want to refuse her.

And he said to them, "My soul is deeply grieved, to the point of death. Remain here and stay awake."