'Pain' in the Bible

any prayer, any supplication that is for any man, and for all Thy people Israel, when they know each his own plague, and his own pain, and he hath spread out his hands towards this house:

Now it came about in the course of time, at the end of two years, that his bowels came out because of his sickness and he died in great pain. And his people made no fire for him like the fire for his fathers.

In his pain Manasseh asked the Lord his God for mercy and truly humbled himself before the God of his ancestors.