Reference: Enmity
Easton
deep-rooted hatred. "I will put enmity between thee and the woman, between thy seed and her seed" (Ge 3:15). The friendship of the world is "enmity with God" (Jas 4:4; 1Jo 2:15-16). The "carnal mind" is "enmity against God" (Ro 8:7). By the abrogation of the Mosaic institutes the "enmity" between Jew and Gentile is removed. They are reconciled, are "made one" (Eph 2:15-16).
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"I'll place hostility between you and the woman, between your offspring and her offspring. He'll strike you on the head, and you'll strike him on the heel."
So she let them down by a rope through the window, since her house was built into the town wall where she lived. She told them, "Go out to the hill country, so the search party won't find you, and hide for three days. After that, you may go on your own way."
That is why the mind that focuses on human nature is hostile toward God. It refuses to submit to the authority of God's Law because it is powerless to do so.
He rendered the Law inoperative, along with its commandments and regulations, thus creating in himself one new humanity from the two, thereby making peace, and reconciling both groups to God in one body through the cross, on which he eliminated the hostility.
You adulterers! Don't you know that friendship with the world means hostility with God? So whoever wants to be a friend of this world is an enemy of God.