'Anguish' in the Bible

"Lord, my servant is lying at home paralyzed, in terrible anguish."

But all these things are merely the beginning of birth pangs [of the intolerable anguish and the time of unprecedented trouble].

And at that time the sign of the Son of Man [coming in His glory] will appear in the sky, and then all the tribes of the earth [and especially Israel] will mourn [regretting their rebellion and rejection of the Messiah], and they will see the Son of Man coming on the clouds of heaven with power and great glory [in brilliance and splendor].

And He took with Him Peter and the two sons of Zabdi. Then He began to be full of anguish and distress,

and He said to them, "My soul is crushed with anguish to the very point of death; wait here, and keep awake with me."