'Insignificant' in the Bible

So Isaiah replied, "Pay attention, family of David. Do you consider it too insignificant to try the patience of men? Is that why you are also trying the patience of my God?

Now the Lord makes this announcement: "Within exactly three years Moab's splendor will disappear, along with all her many people; there will be just a few, insignificant survivors left."

All the nations are insignificant before him; they are regarded as absolutely nothing.

He is the one who reduces rulers to nothing; he makes the earth's leaders insignificant.

Don't be afraid, despised insignificant Jacob, men of Israel. I am helping you," says the Lord, your protector, the Holy One of Israel.

he says, "Is it too insignificant a task for you to be my servant, to reestablish the tribes of Jacob, and restore the remnant of Israel? I will make you a light to the nations, so you can bring my deliverance to the remote regions of the earth."

“For the moth will eat them like a garment,And the worm will eat them like wool.But My righteousness and justice [faithfully promised] will exist forever,And My salvation to all generations.”

He was despised and rejected by people, one who experienced pain and was acquainted with illness; people hid their faces from him; he was despised, and we considered him insignificant.