'Insignificant' in the Bible

Paul replied, "I'm a Jew from Tarsus in Cilicia, a citizen of no insignificant city. Please let me speak to the people."

And God chose what is insignificant in the world, what is despised, what is nothing, in order to destroy what is something,

You know that the saints will rule the world, don't you? And if the world is going to be ruled by you, can't you handle insignificant cases?