'Heaviness' in the Bible

That I have great heaviness and continual sorrow in my heart.

But I determined this with myself, that I would not come again to you in heaviness.

For he longed after you all, and was full of heaviness, because that ye had heard that he had been sick.

Be afflicted, and mourn, and weep: let your laughter be turned to mourning, and your joy to heaviness.

Wherein ye greatly rejoice, though now for a season, if need be, ye are in heaviness through manifold temptations: