And when you hear of wars [going on] and rumors of [other] wars [pending], do not worry, for such things must necessarily happen. But the end has not yet come. [Note: By "end" here Jesus probably alludes to the downfall of Jerusalem in AD 70, with its attending destruction of the Temple buildings].

And when you hear of wars and uprisings [going on], do not be afraid, for such things must necessarily happen first. But the end will not come right away." [Note: By "the end" here Jesus probably alludes to the downfall of Jerusalem, in AD 70, with its attending destruction of the Temple buildings].

See

[But], by holding out steadfastly, you will gain your life. [Note: This means either "preserve your earthly life," or "attain never ending life"].

[Jesus continued], "Do not allow your hearts to be upset. You should believe in God, and believe in me also.

we request that you people do not become shaken up in your mind, nor alarmed, either by a spirit [i.e., by some prophetic prediction], or by a report, or by a letter supposedly from us, that the day of the Lord [i.e., when Jesus returns] has already come.

But even if you have to suffer for doing what was right, you still have [God's] blessing. So, do not be afraid of the threats [of your persecutors], and do not let it worry you.

Must

How [else] then should the Scriptures be fulfilled that this must happen [than what is taking place]?"

For I tell you that this [passage of Scripture], which was written about me, must be fulfilled [Isa. 53:12]: 'And He [i.e., Jesus] was counted with [i.e., as though He were one of] the criminals.' For the part [of that passage] that refers to me is being fulfilled."

saying, 'Do not be afraid Paul, for you must appear before Caesar, and look, God will grant you [the safety of] all these men aboard ship [along] with yourself.'

But

And this good news concerning the kingdom [of heaven] will be preached to people throughout the world as a testimony [of God's message] to all nations. Then, [after that] the end [i.e., of Jerusalem, the Temple, etc.] will come.

General references

But the person who holds out [i.e., remains faithful to God] until the end [i.e., of this time of severe persecution] will be saved [from destruction].