'Great Distress' in the Bible

And, taking with him, Peter and the two sons of Zebedee, he began to be grieved and to be in great distress.

And he taketh Peter and James and John with him, and began to be exceedingly amazed, and in great distress;

Alas! for the women with child, and for them who are giving suck, in those days; for there will be great distress upon the land, and anger against this people.

Since he hath been longing to see, you all, and hath been in great distress, because ye had heard he was sick; -