Mark 13:19

For in those days there will be tribulation, such as has not been from the beginning of the creation which God created until now, and never will be.

But from the beginning of creation God 'made them male and female.'

For then there will be great tribulation, such as has not been from the beginning of the world until now, no, and never will be.

For these are days of vengeance, to fulfil all that is written.

Treasury of Scripture Knowledge

For in those days shall be affliction, such as was not from the beginning of the creation which God created unto this time, neither shall be.

For then there will be great tribulation, such as has not been from the beginning of the world until now, no, and never will be.

For these are days of vengeance, to fulfil all that is written.