Mark 13:19

for there will be such misery in those days as there has never been since the beginning of God's creation until now, and never will be again.

But from the beginning of the creation, 'God made them male and female.

for there will be greater misery then than there has ever been from the beginning of creation until now, or ever will be again.

for those are the days of vengeance, when all that is written in the Scriptures will be fulfilled.

Treasury of Scripture Knowledge

For in those days shall be affliction, such as was not from the beginning of the creation which God created unto this time, neither shall be.

for there will be greater misery then than there has ever been from the beginning of creation until now, or ever will be again.

for those are the days of vengeance, when all that is written in the Scriptures will be fulfilled.