Mark 13:19

For those days will be a time of distress, the like of which has not occurred from the beginning of God's creation until now-- and never will again.

Mark 10:6

But, at the beginning of the Creation, God 'made them male and female.'

Matthew 24:21

for that will be 'a time of great distress, the like of which has not occurred from the beginning of the world down to the present time'--no, nor ever will again.

Luke 21:22-24

For these are to be the Days of Vengeance, when all that Scripture says will be fulfilled.

Treasury of Scripture Knowledge

Summary

For in those days shall be affliction, such as was not from the beginning of the creation which God created unto this time, neither shall be.

Bible References

In those

Matthew 24:21
for that will be 'a time of great distress, the like of which has not occurred from the beginning of the world down to the present time'--no, nor ever will again.
Luke 21:22
For these are to be the Days of Vengeance, when all that Scripture says will be fulfilled.