7 Bible Verses about Despondency, Causes Of

So Jacob tore his clothes [in grief], put on sackcloth and mourned many days for his son. Then all his sons and daughters attempted to console him, but he refused to be comforted and said, “I will go down to Sheol (the place of the dead) in mourning for my son.” And his father wept for him.

This is the writing of Hezekiah king of Judah after he had been sick and had recovered from his illness:
I said, “In mid-life
I am to go through the gates of Sheol (the place of the dead),
I am to be summoned, deprived of the remainder of my years.”

I said, “I will not see the Lord
The Lord in the land of the living;
I will no longer see man among the inhabitants of the world.
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“My dwelling (body) is pulled up and removed from me like a shepherd’s tent;
I have rolled up my life as a weaver [rolls up the finished web].
He cuts me free from the warp [of the loom];
From day to night You bring me to an end.

so instead [of further rebuke, now] you should rather [graciously] forgive and comfort and encourage him, to keep him from being overwhelmed by excessive sorrow.

Now the one who presented his offering on the first day was Nahshon the son of Amminadab, of the tribe of Judah; and his offering was one silver dish, the weight of which was a hundred and thirty shekels, one silver basin of seventy shekels, according to the shekel of the sanctuary, both of them full of fine flour mixed with oil as a grain offering;

For even when we arrived in Macedonia our bodies had no rest, but we were oppressed at every turn—conflicts and disputes without, fears and dread within. But God, who comforts and encourages the depressed and the disquieted, comforted us by the arrival of Titus.

The king was deeply moved and went to the upper room over the gate and wept [in sorrow]. And this is what he said as he walked: “O my son Absalom, my son, my son Absalom! How I wish that I had died instead of you, O Absalom, my son, my son!”

In the morning you will say, ‘I wish it were evening!’ and in the evening you will say, ‘I wish it were morning!’—because of the dread in your heart with which you tremble, and because of the sight of your eyes which you will see.