'Destruction' in the Bible

But when the God of heaven was moved to wrath by our fathers, he gave them up into the hands of Nebuchadnezzar, king of Babylon, the Chaldaean, who sent destruction on this house and took the people away into Babylon.

And may the God who has made it a resting-place for his name send destruction on all kings and peoples whose hands are outstretched to make any change in this or to do damage to this house of God at Jerusalem. I, Darius, have given this order, let it be done with all care.

shall we again break Your commandments and intermarry with the peoples who commit these abominations? Would You not be angry with us to the point of destruction, until there is no remnant nor any who escape?