'Grievous' in the Bible

For I know this, that there will come in amongst you after my departure grievous wolves, not sparing the flock;

And when he was come, the Jews who were come down from Jerusalem stood round, bringing many and grievous charges which they were not able to prove:

For this is the love of God, that we keep his commandments; and his commandments are not grievous.

And the first went and poured out his bowl on the earth; and there came an evil and grievous sore upon the men that had the mark of the beast, and those who worshipped its image.