'Grievously' in the Bible

Son of man, when the land sinneth against me by trespassing grievously, then will I stretch out mine hand upon it, and will break the staff of the bread thereof, and will send famine upon it, and will cut off man and beast from it:

But the house of Israel rebelled against Me in the wilderness. They did not walk in My statutes and they despised and rejected My ordinances, which, if a man keeps, he will live; and they greatly profaned My Sabbaths. Then I decided to pour out My wrath on them in the wilderness, to annihilate them.