'Irreverence' in the Bible

“You shall not profane My holy name [using it to honor an idol, or treating it with irreverence or contempt or as a byword]; but I will be sanctified (set apart as holy) among the Israelites. I am the Lord, who sanctifies and declares you holy,

Because of the transgression [of God’s people—their irreverence and ungodliness] the host will be given over to the wicked horn, along with the regular sacrifice; and righteousness and truth will be flung to the ground, and the horn will do as it pleases [by divine permission] and prosper.