'Pained' in the Bible

Being deeply grieved and extremely distressed, each one of them began to say to Him, “Surely not I, Lord?”

The king was deeply grieved, but because of his oaths and his dinner guests [who might have regarded him as weak], he was unwilling to [break his word and] refuse her.

But when Jesus saw this, He was indignant and He said to them, “Allow the children to come to Me; do not forbid them; for the kingdom of God belongs to such as these.

If your brother is being hurt or offended because of food [that you insist on eating], you are no longer walking in love [toward him]. Do not let what you eat destroy and spiritually harm one for whom Christ died.

And I wrote this same thing to you, so that when I came, I would not be filled with sorrow by those who ought to make me glad, for I trusted in you and felt confident that my joy would be shared by all of you.

yet I am glad now, not because you were hurt and made sorry, but because your sorrow led to repentance [and you turned back to God]; for you felt a grief such as God meant you to feel, so that you might not suffer loss in anything on our account.