'Painful' in the Bible

But to Adam he said, "Because you obeyed your wife and ate from the tree about which I commanded you, 'You must not eat from it,' cursed is the ground thanks to you; in painful toil you will eat of it all the days of your life.

He named him Noah, saying, "This one will bring us comfort from our labor and from the painful toil of our hands because of the ground that the Lord has cursed."

Then the Lord's angel said to her, "You are now pregnant and are about to give birth to a son. You are to name him Ishmael, for the Lord has heard your painful groans.

Jacob said to Pharaoh, "All the years of my travels are 130. All the years of my life have been few and painful; the years of my travels are not as long as those of my ancestors."