'Significance' in the Bible

Then I looked, and I heard a solitary eagle crying in a loud voice, as it flew across the sky, "Alas, alas, alas, for the inhabitants of the earth, because of the significance of the remaining trumpets which the three angels are about to blow!"

And a great sign [warning of an ominous and frightening future event] appeared in heaven: a woman clothed with the sun, with the moon beneath her feet, and on her head a crown of twelve stars.

Then I saw another sign in heaven, great and wonderful [a warning of terrifying and horrible events]: seven angels who had seven plagues (afflictions, calamities), which are the last, because with them the wrath of God is finished [that is, it is completely expressed and reaches its zenith].