'Significance' in the Bible

"I wanted to learn the precise significance of the fourth animal that was different from all the others, extremely awe-inspiring, with iron teeth and bronze claws, and that had devoured and crushed things, trampling under its feet whatever remained.

Also, I wanted to learn the significance of the ten horns on its head and the other horn that had arisen, before which three of them had fallen that is, the horn with eyes and a mouth that uttered magnificent things and which was greater in appearance than its fellows.

because they didn't understand the significance of the loaves. Instead, their hearts were hardened.