'Insignificant' in the Bible

“Though your beginning was insignificant,Yet your end will increase greatly.

“His sons achieve honor, but he does not know it;Or they become insignificant, but he does not perceive it.

“They are insignificant on the surface of the water;Their portion is cursed on the earth.They do not turn toward the vineyards.

“Behold, I am insignificant; what can I reply to You?I lay my hand on my mouth.