'Insignificant' in the Bible

“Though your beginning was insignificant,Yet your end will increase greatly.

If his sons receive honor, he does not know it;if they become insignificant, he is unaware of it.

“They are insignificant on the surface of the water;Their portion is cursed on the earth.They do not turn toward the vineyards.

who {shows no partiality to officials} and [who] {does not take note of the noble more than of the insignificant}, for all of them [are] the work of his hands?

I am so insignificant. How can I answer You?I place my hand over my mouth.