'Ripe' in the Bible

Then another angel came out of the temple, shouting in a loud voice to the one seated on the cloud, "Use your sickle and start to reap, because the time to reap has come, since the earth's harvest is ripe!"

Another angel, who was in charge of the fire, came from the altar and called in a loud voice to the angel who had the sharp sickle, "Use your sharp sickle and gather the clusters of grapes off the vine of the earth, because its grapes are now ripe."

(The ripe fruit you greatly desired has gone from you, and all your luxury and splendor have gone from you -- they will never ever be found again!)