'Anguish Of Heart' in the Bible

And he took Peter, James, and John along with Him, and He began to feel completely dazed and to realize His anguish of heart,

And when they saw him, they were struck with surprise; and his mother said to him, Son, why hast thou behaved to us in this manner? lo! thy father and I have been seeking thee in anguish of heart.

when I declare that I have deep grief and unceasing anguish of heart.

For out of much affliction and anguish of heart I wrote unto you with many tears; not that ye should be grieved, but that ye might know the love which I have more abundantly unto you.