'Anguish Of Heart' in the Bible

And when they saw him, they were struck with surprise; and his mother said to him, Son, why hast thou behaved to us in this manner? lo! thy father and I have been seeking thee in anguish of heart.

For out of much affliction and anguish of heart I wrote unto you with many tears, not that ye should be grieved, but that ye might know the love which I have more abundantly towards you.