'Sin Against' in the Bible

He has no greater [authority] in this house than me, and he has not withheld anything from me except you, since you [are] his wife. Now how could I do this great wickedness and sin against God?"

Then Reuben answered them, saying, "Did I not say to you, do not sin against the boy? But you did not listen, and now, behold, his blood has been sought."