'Sin Against' in the Bible

There is no one greater in this house than I, neither hath he withheld from me anything, save only thyself in that thou, art his wife, - how, then could I do this great wickedness, and sin against God?

And Reuben responded to them, saying - Spake I not unto you saying, Do not sin against the child! And ye hearkened not? His very blood, therefore lo! it is required.