He named the second [son] Ephraim (fruitfulness), for “God has caused me to be fruitful and very successful in the land of my suffering.”

Now to Joseph in the land of Egypt were born Manasseh and Ephraim, whom Asenath, the daughter of Potiphera, priest of On (Heliopolis in Egypt), bore to him.

Now some time after these things happened, Joseph was told, “Your father is sick.” So he took his two sons Manasseh and Ephraim with him [to go to Goshen].

Now your two sons [Ephraim and Manasseh], who were born to you in the land of Egypt before I came to you in Egypt, are mine; Ephraim and Manasseh shall be mine [that is, adopted as my heirs and sons as surely], as Reuben and Simeon are my sons.

Then Joseph took them both, Ephraim with his right hand toward Israel’s left, and Manasseh with his left hand toward Israel’s right, and brought them close to him.

But Israel reached out his right hand and laid it on the head of Ephraim, who was the younger, and his left hand on Manasseh’s head, crossing his hands [intentionally], even though Manasseh was the firstborn.

When Joseph saw that his father laid his right hand on Ephraim’s head, it displeased him [because he was not the firstborn]; and he grasped his father’s hand to move it from Ephraim’s head to Manasseh’s head.

Then Jacob blessed them that day, saying,

“By you Israel will pronounce a blessing, saying,
‘May God make you like Ephraim and Manasseh.’”

And he put Ephraim before Manasseh.

Joseph saw the third generation of Ephraim’s children; also the children of Machir, the son of Manasseh, were born and raised on Joseph’s knees.