After this I kept looking, and behold, another one (the Greek Empire of Alexander the Great), like a leopard, which had on its back four wings like those of a bird; the beast also had four heads (Alexander’s generals, his successors), and power to rule was given to it.

But as soon as he (Alexander) has risen, his kingdom will be broken [by his death] and divided toward the four winds of heaven [the north, south, east, and west], but not to his descendants, nor according to the [Grecian] authority with which he ruled, for his kingdom will be torn out and uprooted and given to others (his four generals) to the exclusion of these.

He was talking and arguing with the Hellenists (Greek-speaking Jews); but they were attempting to kill him.