'Bitter' in the Bible

The ways of Zion are sad, because no one comes to the holy meeting; all her doorways are made waste, her priests are breathing out sorrow: her virgins are troubled, and it is bitter for her.

He has put up a wall against me, shutting me in with bitter sorrow.

He has made my life nothing but pain, he has given me the bitter root in full measure.

Keep in mind my trouble and my wandering, the bitter root and the poison.

Their bitter words have come to your ears, O Lord, and all their designs against me;