'Upon' in the Bible

[I am writing about] what existed from the beginning, what we have heard, what we have seen with our eyes, what we have looked at and touched with our hands, concerning the Word of Life [the One who existed even before the beginning of the world, Christ]—

You know that He appeared [in visible form as a man] in order to take away sins; and in Him there is [absolutely] no sin [for He has neither the sin nature nor has He committed sin or acts worthy of blame].