'Alienated' in the Bible

Ah, sinful nation,A people loaded down with wickedness [with sin, with injustice, with wrongdoing],Offspring of evildoers,Sons who behave corruptly!They have abandoned (rejected) the Lord,They have despised the Holy One of Israel [provoking Him to anger],They have turned away from Him.

“Be wise and be warned, O Jerusalem,Or I will be alienated from you,And make you a desolation,An uninhabited land.”