'Alienated' in the Bible

Ah, sinful nation,A people loaded down with wickedness [with sin, with injustice, with wrongdoing],Offspring of evildoers,Sons who behave corruptly!They have abandoned (rejected) the Lord,They have despised the Holy One of Israel [provoking Him to anger],They have turned away from Him.

“Be wise and be warned, O Jerusalem,Or I will be alienated from you,And make you a desolation,An uninhabited land.”

You see and hear that not only at Ephesus, but almost all over [the province of] Asia, this Paul has persuaded [people to believe his teaching] and has misled a large number of people, claiming that gods made by [human] hands are not really gods at all.

for their [moral] understanding is darkened and their reasoning is clouded; [they are] alienated and self-banished from the life of God [with no share in it; this is] because of the [willful] ignorance and spiritual blindness that is [deep-seated] within them, because of the hardness and insensitivity of their heart.

And although you were at one time estranged and alienated and hostile-minded [toward Him], participating in evil things,