'Anguish' in the Bible

When they saw Him, they were smitten with amazement, and His mother said to Him, "My child, why have you behaved thus to us? Your father and I have been searching for you in anguish."

"There will be signs in sun, moon, and stars; and on earth anguish among the nations in their bewilderment at the roaring of the sea and its billows;