'Bitter' in the Bible

"How terrible it will be for those who call evil good and good evil, who substitute darkness for light and light for darkness, who substitute what is bitter for what is sweet and what is sweet for what is bitter!"

Therefore I said: "Look away from me; and let me weep bitter tears; don't try to console me over the destruction of the daughter of my people."

No longer do they drink wine accompanied by singing; even beer tastes bitter to those who drink it.

I said, "Must I leave in the prime of my life? Must I be consigned to the control of Sheol? Bitter are my years!"