'Bitterly' in the Bible

Hannah was greatly distressed, and she prayed to the Lord and wept in anguish.

Then Samuel said to Saul, “Why have you disturbed me by bringing me up?” Saul answered, “I am greatly distressed; for the Philistines are making war against me, and God has left me and no longer answers me, either through prophets or by dreams; therefore I have called you to make known to me what I should do.”

Further, David was greatly distressed because the people spoke of stoning him, for all of them were embittered, each man for his sons and daughters. But David felt strengthened and encouraged in the Lord his God.