'Bitterness' in the Bible

The ways of Zion do mourn, because none come to the solemn feasts: all her gates are desolate: her priests sigh, her virgins are afflicted, and she is in bitterness.

In the days of her affliction and homelessnessJerusalem remembers all her precious thingsThat she had from the days of old,When her people fell into the hand of the adversary,And no one helped her,The enemy saw her,They mocked at her downfall.

He has laid siege against me,encircling me with bitterness and hardship.

He hath filled me with bitterness, he hath made me drunken with wormwood.

Remember my affliction and my wandering, the wormwood and bitterness.