'Bitterness' in the Bible

Therefore I will not refrain my mouth; I will speak in the anguish of my spirit; I will complain in the bitterness of my soul.

He will not suffer me to take my breath, but filleth me with bitterness.

My soul is weary of my life; I will leave my complaint upon myself; I will speak in the bitterness of my soul.

His food in his bowels is turned, The bitterness of asps is in his heart.

And another dieth in the bitterness of his soul, and never eateth with pleasure.