'Trouble' in the Bible

And you took us and the Lord as your example, after the word had come to you in much trouble, with joy in the Holy Spirit;

For you have the memory, my brothers, of our trouble and care; how, working night and day, so that we might not be a trouble to any of you, we gave you the good news of God.

And when we were with you, we said to you that trouble was before us; and so it came about, as you see.

For this cause, brothers, in all our trouble and grief we were comforted about you because of your faith;