Mark 13:19
There will be great trouble during those days, such as had never been from the beginning of God's creation until the present, or even will be [in the days to come].
Mark 10:6
But from the beginning of creation God made mankind male and female.
Matthew 24:21
There will be great trouble [during these times], such as had never been from the beginning of time up to the present, or ever will be [in the days to come].
Luke 21:22-24
For these are times for punishment [i.e., to be inflicted on Jerusalem], so that everything written [i.e., by the prophets] may be fulfilled [i.e., about Jerusalem's destruction. See Dan. 9:26-27].