Mark 13:19

There will be great trouble during those days, such as had never been from the beginning of God's creation until the present, or even will be [in the days to come].

Mark 10:6

But from the beginning of creation God made mankind male and female.

Matthew 24:21

There will be great trouble [during these times], such as had never been from the beginning of time up to the present, or ever will be [in the days to come].

Luke 21:22-24

For these are times for punishment [i.e., to be inflicted on Jerusalem], so that everything written [i.e., by the prophets] may be fulfilled [i.e., about Jerusalem's destruction. See Dan. 9:26-27].

Treasury of Scripture Knowledge

Summary

For in those days shall be affliction, such as was not from the beginning of the creation which God created unto this time, neither shall be.

Bible References

In those

Matthew 24:21
There will be great trouble [during these times], such as had never been from the beginning of time up to the present, or ever will be [in the days to come].
Luke 21:22
For these are times for punishment [i.e., to be inflicted on Jerusalem], so that everything written [i.e., by the prophets] may be fulfilled [i.e., about Jerusalem's destruction. See Dan. 9:26-27].