'Vain' in the Bible

And I went up by revelation, and communicated unto them that gospel which I preach among the Gentiles, but privately to them which were of reputation, lest by any means I should run, or had run, in vain.

I do not frustrate the grace of God: for if righteousness come by the law, then Christ is dead in vain.

Have ye suffered so many things in vain? if it be yet in vain.

I am afraid of you, lest I have bestowed upon you labour in vain.