'Anguish' in the Bible

“Then there will be signs in the sun, moon, and stars; and there will be anguish on the earth among nations bewildered by the roaring sea and waves.

Being in anguish, He prayed more fervently, and His sweat became like drops of blood falling to the ground.]

Who can separate us from the love of Christ?Can affliction or anguish or persecutionor famine or nakedness or danger or sword?

that I have intense sorrow and continual anguish in my heart.