'Depressed' in the Bible

And taking with Him Peter and the two sons of Zebedee [James and John], He began to be grieved and greatly distressed.

He took Peter and James and John with Him, and He began to be deeply distressed and troubled [extremely anguished at the prospect of what was to come].

“But be on guard, so that your hearts are not weighed down and depressed with the giddiness of debauchery and the nausea of self-indulgence and the worldly worries of life, and then that day [when the Messiah returns] will not come on you suddenly like a trap;

So for now you are in grief; but I will see you again, and [then] your hearts will rejoice, and no one will take away from you your [great] joy.

For while we are in this tent, we groan, being burdened [often weighed down, oppressed], not that we want to be unclothed [separated by death from the body], but to be clothed, so that what is mortal [the body] will be swallowed up by life [after the resurrection].

But God, who comforts and encourages the depressed and the disquieted, comforted us by the arrival of Titus.