'Malignant' in the Bible

Then it goes and brings with it seven other spirits more malignant than itself, and they enter and dwell there; and in the end that man's condition becomes worse than it was at first.

There will be violent earthquakes, and in various places famines and [deadly and devastating] pestilences (plagues, epidemics); and there will be terrible sights and great signs from heaven.

So the first angel went and poured out his bowl on the earth; and it became a loathsome and malignant sore on the people who had the mark of the beast and who worshiped his image.