'Bitter' in the Bible

Now the Jews said bitter things about Jesus because of his words, I am the bread which came down from heaven.

If, to avoid breaking the Law of Moses, a man undergoes circumcision on the Sabbath, why are you angry with Me for making a man’s whole body well on the Sabbath?

Now there was a vessel ready, full of bitter wine, and they put a sponge full of it on a stick and put it to his mouth.