'Bitter' in the Bible

Is not this the woodworker, the son of Mary, and brother of James and Joses and Judas and Simon? and are not his sisters here with us? And they were bitter against him.

And Herodias was bitter against him, desiring to put him to death; but she was not able;

And one of them went quickly and, getting a sponge full of bitter wine, put it on a rod, and gave it to him for drink, saying, Let be; let us see if Elijah will come to take him down.