'Bitter' in the Bible

For I see you are in {a state of bitter envy} and {bound by unrighteousness}."

And he was in bitter hostility with the Tyrians and Sidonians; but they came to him with one accord, and, having gained Blastus the king's chamberlain, sought peace, because their country was nourished by the king's.

But those Jews who had not the faith, made the minds of the Gentiles bitter against the brothers.

And I often punished them [making them suffer] in all the synagogues and tried to force them to blaspheme; and in my extreme rage at them, I kept hunting them even to foreign cities [harassing and persecuting them].