'Irritation' in the Bible

Then Moses reported this to the Israelis, but they did not listen to Moses due to their irritation and impatience because there was no deliverance and because of the cruel bondage.

“Now Job has not directed his words against me [therefore I have no reason to be offended],Nor will I answer him with arguments like yours. [I speak for truth, not for revenge.]

All his days also he eateth in darkness, and hath much vexation, and sickness, and irritation.