'Painful' in the Bible

Then the hand of the Lord was heavy on the people of Ashdod, and He caused them to be dumbfounded and struck them with tumors, both Ashdod and its territory.

The men who had not died were stricken with tumors and the cry of the city [for help] went up to heaven.

So Satan departed from the presence of the Lord and struck Job with loathsome boils and agonizingly painful sores from the sole of his foot to the crown of his head.

When I considered how to understand this,It was too great an effort for me and too painful

I have seen the task which God has given to the sons of men with which to occupy themselves.

I have seen that every [effort in] labor and every skill in work comes from man’s rivalry with his neighbor. This too is vanity (futility, false pride) and chasing after the wind.

One hand full of rest and patience is better than two fists full of labor and chasing after the wind.

There was a certain man—without a dependent, having neither a child nor a brother, yet there was no end to all his labor. Indeed, his eyes were not satisfied with riches and he never asked, “For whom do I labor and deprive myself of pleasure?” This too is vanity (a wisp of smoke, self-conceit); yes, it is a painful effort and an unhappy task.

For the dream comes through much effort, and the voice of the fool through many words.

When I applied my mind to know wisdom and to see the activities [of mankind] that take place upon the earth—how some men seem to sleep neither day nor night—

While he was seated on the judgment seat, his wife sent him a message, saying, “Have nothing to do with that righteous and innocent Man; for last night I suffered greatly in a dream because of Him.”

But I made up my mind not to grieve you with another painful visit.

But remember the earlier days, when, after being [spiritually] enlightened, you [patiently] endured a great conflict of sufferings,

For the time being no discipline brings joy, but seems sad and painful; yet to those who have been trained by it, afterwards it yields the peaceful fruit of righteousness [right standing with God and a lifestyle and attitude that seeks conformity to God’s will and purpose].

So the first angel went and poured out his bowl on the earth; and loathsome and malignant sores came on the people who had the mark of the beast and who worshiped his image.